Microsoft just released the following blog post on the support of Data Deduplication on Windows Server 2012 R2 in combination with System Center 2012 R2 Configuration Manager.
Then Johan (@Jarwidmark) published his post on how to actually configure deduplication and a small summary on the support statement:
Enable Data Deduplication for ConfigMgr with Powershell
If you don’t want to enable it all manually, then just use this code snippet inside an administrative Powershell.
Just change line 6 and enter the Volume you like to enable Deduplication on and do the same in line 9.
In line 9 you should also add any exclusions you want. Like Johan and the MS article stated, don’t enable dedup for your Content Source!
#Install the feature Import-Module ServerManager Add-WindowsFeature -Name FS-Data-Deduplication #Enable on volume Enable-DedupVolume D: # Set exclusions Set-DedupVolume –Volume D: -ExcludeFolder 'D:\ContentSource'
Have fun saving space!